Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Micronutrient deficiency and depression are major global health problems. Here, we first
review recent empirical evidence of the association between several micronutrients—zinc …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Background Attention-deficit/hyperactivity disorder (ADHD) is a significant neurobehavioral
disorder in children and adolescence which may be affected by diet. Objective To evaluate …

Abstract Zinc transporter 3 (ZnT3) is the sole mechanism responsible for concentrating zinc
ions within synaptic vesicles in a subset of the brain's glutamatergic neurons. This vesicular …

Decades after the discovery that ionic zinc is present at high levels in glutamatergic synaptic
vesicles, where, when, and how much zinc is released during synaptic activity remains …

The emergence of mental disorders is associated with several risk factors including genetic
and environmental susceptibility. A group of nutrients serves an especially important role in …

Stimulus-specific adaptation is a hallmark of sensory processing in which a repeated
stimulus results in diminished successive neuronal responses, but a deviant stimulus will …

The divalent cation, zinc is the second most abundant metal in the human body and is
indispensable for life. Zinc concentrations must however, be tightly regulated as deficiencies …

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of
cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical …