Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Osteoarthritis pathogenesis: a review of molecular mechanisms

B Xia, D Chen, J Zhang, S Hu, H Jin, P Tong - Calcified tissue international, 2014 - Springer
Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …

[HTML][HTML] Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score)

DJ Hunter, A Guermazi, GH Lo, AJ Grainger… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: In an effort to evolve semi-quantitative scoring methods based upon limitations
identified in existing tools, integrating expert readers' experience with all available scoring …

The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis

LS Lohmander, PM Englund… - The American journal …, 2007 - journals.sagepub.com
The objectives of this study are to review the long-term consequences of injuries to the
anterior cruciate ligament and menisci, the pathogenic mechanisms, and the causes of the …

MMP13 is a critical target gene during the progression of osteoarthritis

M Wang, ER Sampson, H Jin, J Li, QH Ke, HJ Im… - Arthritis research & …, 2013 - Springer
Introduction Osteoarthritis (OA) is a degenerative joint disease affecting a large population of
people. The mechanism of this highly prevalent disease is not fully understood. Currently …

Incidental meniscal findings on knee MRI in middle-aged and elderly persons

M Englund, A Guermazi, D Gale… - … England Journal of …, 2008 - Mass Medical Soc
Background Magnetic resonance imaging (MRI) of the knee is often performed in patients
who have knee symptoms of unclear cause. When meniscal tears are found, it is commonly …

Biomechanical consequences of a tear of the posterior root of the medial meniscus: similar to total meniscectomy

R Allaire, M Muriuki, L Gilbertson, CD Harner - JBJS, 2008 - journals.lww.com
Background: Tears of the posterior root of the medial meniscus are becoming increasingly
recognized. They can cause rapidly progressive arthritis, yet their biomechanical effects are …

Meniscus pathology, osteoarthritis and the treatment controversy

M Englund, FW Roemer, D Hayashi… - Nature Reviews …, 2012 - nature.com
The menisci are internal structures that are of central importance for a healthy knee joint;
they have a key role in the structural progression of knee osteoarthritis (OA), and the risk of …

[HTML][HTML] OARSI-FDA initiative: defining the disease state of osteoarthritis

NE Lane, K Brandt, G Hawker, E Peeva… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: To respond to a pre-specified set of questions posed by the United States Food
and Drug Administration (FDA) on defining the disease state to inform the clinical …

Higher dynamic medial knee load predicts greater cartilage loss over 12 months in medial knee osteoarthritis

KL Bennell, KA Bowles, Y Wang, F Cicuttini… - Annals of the …, 2011 - ard.bmj.com
Objective Mechanical factors, in particular increased medial knee joint load, are believed to
be important in the structural progression of knee osteoarthritis. This study evaluated the …