Liquid–liquid phase separation drives cellular function and dysfunction in cancer
S Mehta, J Zhang - Nature Reviews Cancer, 2022 - nature.com
Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …
Ewing's sarcoma
N Riggi, ML Suvà, I Stamenkovic - New England Journal of …, 2021 - Mass Medical Soc
Ewing's Sarcoma Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
Phase separation drives aberrant chromatin looping and cancer development
The development of cancer is intimately associated with genetic abnormalities that target
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies …
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies …
Imaging dynamic and selective low-complexity domain interactions that control gene transcription
INTRODUCTION DNA binding transcription factors (TFs) are quintessential regulators of
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
Phase separation: linking cellular compartmentalization to disease
A Aguzzi, M Altmeyer - Trends in cell biology, 2016 - cell.com
Eukaryotic cells are complex structures capable of coordinating numerous biochemical
reactions in space and time. Key to such coordination is the subdivision of intracellular …
reactions in space and time. Key to such coordination is the subdivision of intracellular …
Cancer-specific retargeting of BAF complexes by a prion-like domain
Alterations in transcriptional regulators can orchestrate oncogenic gene expression
programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin …
programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin …
Genetic mutations in RNA-binding proteins and their roles in ALS
K Kapeli, FJ Martinez, GW Yeo - Human genetics, 2017 - Springer
Mutations in genes that encode RNA-binding proteins (RBPs) have emerged as critical
determinants of neurological diseases, especially motor neuron disorders such as …
determinants of neurological diseases, especially motor neuron disorders such as …
Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export
The toxic proline: arginine (PRn) poly-dipeptide encoded by the (GGGGCC) n repeat
expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the …
expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the …
Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos
The regulation of transcription requires the coordination of numerous activities on DNA, yet
how transcription factors mediate these activities remains poorly understood. Here, we use …
how transcription factors mediate these activities remains poorly understood. Here, we use …
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like …
C Colombrita, E Onesto, F Megiorni, A Pizzuti… - Journal of Biological …, 2012 - ASBMB
The RNA-binding proteins TDP-43 and FUS form abnormal cytoplasmic aggregates in
affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar …
affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar …