Very long-chain fatty acids (VLCFAs) are fatty acids (FAs) with a chain-length of≥ 22
carbons. Mammals have a variety of VLCFAs differing in chain-length and the number of …

Ceramide (Cer) is a structural backbone of sphingolipids and is composed of a long-chain
base and a fatty acid. Existence of a variety of Cer species, which differ in chain-length …

Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of
double bonds. FAs with C> 20 are called very long-chain fatty acids (VLCFAs). VLCFAs are …

Lipid metabolism plays a major role in the regulation of the immune system. Exogenous
(dietary and microbial-derived) and endogenous (non-microbial-derived) lipids play a direct …

Cisplatin and other platinum (II) analogs are widely used in clinical practice as anti-cancer
drugs for a wide range of tumors. The primary mechanism by which they exert their action is …

Ceramide is located at a key hub in the sphingolipid metabolic pathway and also acts as an
important cellular signaling molecule. Ceramide contains one acyl chain which is attached …

Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and
other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on …

The endoplasmic reticulum (ER) is not only important for protein synthesis and folding but is
also crucial for lipid synthesis and metabolism. In the current study, we demonstrate an …

Summary ACOX1 (acyl-CoA oxidase 1) encodes the first and rate-limiting enzyme of the
very-long-chain fatty acid (VLCFA) β-oxidation pathway in peroxisomes and leads to H 2 O 2 …

Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …