[HTML][HTML] TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis

Y Hao, D Baker, P Ten Dijke - International journal of molecular sciences, 2019 - mdpi.com
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

[HTML][HTML] Cancer drug resistance induced by EMT: novel therapeutic strategies

J De Las Rivas, A Brozovic, S Izraely, A Casas-Pais… - Archives of …, 2021 - Springer
Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

TGF-β signaling in cancer metastasis

F Xie, L Ling, H Van Dam, F Zhou… - Acta biochimica et …, 2018 - academic.oup.com
The transforming growth factor (TGF)-β signaling events are well known to control diverse
processes and numerous responses, such as cell proliferation, differentiation, apoptosis …

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Z Huang, Z Zhang, C Zhou, L Liu, C Huang - MedComm, 2022 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

[HTML][HTML] Exosomal miR-21-5p derived from gastric cancer promotes peritoneal metastasis via mesothelial-to-mesenchymal transition

Q Li, B Li, Q Li, S Wei, Z He, X Huang, L Wang… - Cell death & …, 2018 - nature.com
Peritoneal metastasis is a primary metastatic route for gastric cancers, and the mechanisms
underlying this process are still unclear. Peritoneal mesothelial cells (PMCs) undergo …

[HTML][HTML] Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-β signalling

W Huang, Y Yang, J Wu, Y Niu, Y Yao… - Cell Death & …, 2020 - nature.com
Circular RNAs (circRNAs) are novel RNA molecules that play important roles in
chemoresistance in different cancers, including breast and gastric cancers. However …

miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression

C Ma, D He, P Tian, Y Wang, Y He… - Proceedings of the …, 2022 - National Acad Sciences
The protumor roles of alternatively activated (M2) tumor-associated macrophages (TAMs)
have been well established, and macrophage reprogramming is an important therapeutic …

[HTML][HTML] MicroRNA control of TGF-β signaling

HI Suzuki - International journal of molecular sciences, 2018 - mdpi.com
Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome
changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small …

[HTML][HTML] miR-190 suppresses breast cancer metastasis by regulation of TGF-β-induced epithelial–mesenchymal transition

Y Yu, W Luo, ZJ Yang, JR Chi, YR Li, Y Ding, J Ge… - Molecular cancer, 2018 - Springer
Background Breast cancer is the most common cancer among women worldwide and
metastasis is the leading cause of death among patients with breast cancer. The …

[HTML][HTML] The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression

H Hong, H Zhu, S Zhao, K Wang, N Zhang, Y Tian… - Cell Death & …, 2019 - nature.com
As a new class of non-coding RNA, circular RNAs (circRNAs) play crucial roles in the
development and progression of various cancers. However, the detailed functions of …