Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …

Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …

Context Treatment of metastatic urothelial carcinoma is currently undergoing a rapid
evolution. Objective This overview presents the updated European Association of Urology …

Background The responses of cancer patients to immune checkpoint inhibitors (ICIs) vary in
success. CD8+ tumor infiltrating lymphocytes (TILs) play a key role in killing tumor cells. This …

A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in
breast cancers, but its heterogeneity and its impact on immunotherapy response remain …

Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and
this is quite different from the common cell death patterns such as apoptosis, pyroptosis …

Importance PD-L1 (programmed cell death ligand 1) immunohistochemistry (IHC), tumor
mutational burden (TMB), gene expression profiling (GEP), and multiplex …

Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and
development in bladder cancer. However, the underlying molecular mechanisms remain …