The prevalence of chronic viral infectious diseases, such as human immunodeficiency virus
(HIV), hepatitis C virus (HCV), and influenza virus; the emergence and re-emergence of new …

Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …

Introduction: Rhodanine-based compounds have been associated with numerous biological
activities. After many years of research in drug discovery, they have gained a reputation as …

The emerging and re-emerging viral infections are constant threats to human health and
wellbeing. Several strategies have been explored to develop vaccines against these viral …

Recently, inhibition effects of enzymes such as acetylcholinesterase (AChE) and carbonic
anhydrase (CA) has appeared as a promising approach for pharmacological intervention in …

The rapid enantioselective synthesis of valuable building blocks and pharmaceutically
important compounds from easily accessible precursors is one of the major areas of focus in …

The envelope glycoprotein complex (Env) is responsible for entry of the human
immunodeficiency virus type 1 (HIV-1) into cells by mediating attachment to target cells and …

As an important aspect of computer-aided drug design, structure-based drug design brought
a new horizon to pharmaceutical development. This in silico method permeates all aspects …

In continuing our search for novel tyrosinase inhibitors, a series of 5-(substituted
benzylidene) thiazolidine-2, 4-diones were rationally designed and synthesized, and their …

Entry of human immunodeficiency virus type 1 (HIV-1) into cells is mediated by attachment of
the envelope glycoproteins, gp120 and gp41, to the CD4 receptor and a chemokine receptor …