Molecular mechanisms of gasdermin D pore-forming activity
The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …
from embryonic development, organ maintenance, and aging to the coordination of immune …
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism
V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
Channelling inflammation: gasdermins in physiology and disease
Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …
[HTML][HTML] Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity
Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation
NOD-like receptor (NLR), family pyrin domain containing 3 (NLRP3) assembles a protein
complex known as the NLRP3 inflammasome upon sensing certain pathogen products or …
complex known as the NLRP3 inflammasome upon sensing certain pathogen products or …
Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice
M Yan, Y Li, Q Luo, W Zeng, X Shao, L Li, Q Wang… - Cell Death …, 2022 - nature.com
Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently
lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon …
lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon …
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
[HTML][HTML] Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis
R Yuan, W Zhao, QQ Wang, J He, S Han, H Gao… - Pharmacological …, 2021 - Elsevier
Pyroptosis, a type of programmed cell death (PCD), is characterized by cell swelling with
bubbles, and the release of inflammatory cell cytokines. Cucurbitacin B (CuB), extracted …
bubbles, and the release of inflammatory cell cytokines. Cucurbitacin B (CuB), extracted …