Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and …

D Mokra, M Joskova, J Mokry - International journal of molecular sciences, 2022 - mdpi.com
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Q Yan, S Liu, Y Sun, C Chen, S Yang, M Lin… - Journal of Translational …, 2023 - Springer
Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

Quercetin ameliorates diabetic kidney injury by inhibiting ferroptosis via activating Nrf2/HO-1 signaling pathway

Q Feng, Y Yang, Y Qiao, Y Zheng, X Yu… - The American Journal …, 2023 - World Scientific
Diabetic nephropathy (DN) is thought to be the major cause of end-stage renal disease. Due
to its complicated pathogenesis and the low efficacy of DN treatment, a deep understanding …

[HTML][HTML] Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting …

CY Lian, BX Chu, WH Xia, ZY Wang, RF Fan… - Journal of advanced …, 2023 - Elsevier
Abstract Introduction Lead (Pb) is an environmental toxicant that poses severe health risks to
humans and animals, especially renal disorders. Pb-induced nephrotoxicity has been …

Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway

Q Jiang, X Chen, X Tian, J Zhang, S Xue, Y Jiang, T Liu… - Phytomedicine, 2022 - Elsevier
Background Doxorubicin (DOX) is a powerful anti-tumor anthracycline drug. However, its
clinical use is limited due to the side effect of cardiotoxicity. Tanshinone I (Tan I) is one of the …

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases

RM Kamal, AF Abdull Razis, NS Mohd Sukri… - Molecules, 2022 - mdpi.com
Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that
affect the nervous system and heart, all of which are vital to the human body. To maintain …

Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants

YQ Shi, XT Zhu, SN Zhang, YF Ma, YH Han… - Frontiers in …, 2023 - frontiersin.org
Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

[HTML][HTML] Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural …

T Zhang, W Deng, Y Deng, Y Liu, S Xiao, Y Luo… - Biomedicine & …, 2023 - Elsevier
Acute myocardial infarction remains the leading cause of death in humans. Timely
restoration of blood perfusion to ischemic myocardium remains the most effective strategy in …

[HTML][HTML] HgCl2 exposure mediates pyroptosis of HD11 cells and promotes M1 polarization and the release of inflammatory factors through ROS/Nrf2/NLRP3

J Wang, Y Yin, Q Zhang, X Deng, Z Miao… - … and environmental safety, 2024 - Elsevier
Mercury (Hg) is a serious metal environmental pollutant. HgCl 2 exposure causes
pyroptosis. When macrophages are severely stimulated, they often undergo M1 polarization …