Recent advances in medical treatments have been revolutionary in shaping the
management and treatment landscape of patients, notably cancer patients. Over the last …

Retinal fibrosis, characterized by dysregulation of extracellular matrix (ECM) protein
deposition by retinal endothelial cells, pigment epithelial cells, and other resident cell-types …

Tissue fibrosis is characterized by excessive deposition of extracellular matrix (ECM)
molecules. Fibronectin (FN) is a glycoprotein found in the blood and tissues, a key player in …

Few data exist regarding the protein composition of idiopathic epiretinal membrane (iERM).
In the present study we compared the proteome of epiretinal membrane of iERM with the …

Corneal wound healing requires epithelial reorganization and stromal extracellular matrix
(ECM) remodeling, with ECM proteins such as Tenascin C (TnC) regulating and maintaining …

The fibronectin matrix plays a crucial role in the regulation of angiogenesis during
development, tissue repair and pathogenesis. Previous work has identified a fibronectin …

Purpose: Proliferative vitreoretinopathy (PVR) remains an unresolved clinical challenge and
can lead to frequent revision surgery and blindness vision loss. The aim of this study was to …

The dental epithelium and extracellular matrix interact to ensure that cell growth and
differentiation lead to the formation of teeth of appropriate size and quality. To determine the …

Background: The epithelial to mesenchymal transition (EMT) of retinal pigment epithelial
(RPE) cells is a critical event in the pathogenesis of proliferative vitreoretinopathy and …

TGF-β and myofibroblasts play a key role in fibrosis, characterized by aberrant synthesis and
deposition of extracellular matrix (ECM) proteins, such as fibronectin (Fn) and collagen type …