The role of leptin in regulating bone metabolism

J Upadhyay, OM Farr, CS Mantzoros - Metabolism, 2015 - Elsevier
Leptin was initially best known for its role in energy homeostasis and regulation of energy
expenditure. In the past few years we have realized that leptin also plays a major role in …

Cellular and molecular mechanisms associating obesity to bone loss

YS Forte, M Renovato-Martins, C Barja-Fidalgo - Cells, 2023 - mdpi.com
Obesity is an alarming disease that favors the upset of other illnesses and enhances
mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The …

Molecular mechanisms of obesity-induced osteoporosis and muscle atrophy

B Roy, ME Curtis, LS Fears, SN Nahashon… - Frontiers in …, 2016 - frontiersin.org
Obesity and osteoporosis are two alarming health disorders prominent among middle and
old age populations, and the numbers of those affected by these two disorders are …

Cytokines, adipokines, and bone markers at rest and in response to plyometric exercise in obese vs normal weight adolescent females

N Kurgan, K McKee, M Calleja, AR Josse… - Frontiers in …, 2020 - frontiersin.org
Background In adults, excess adiposity has been associated with low-grade, chronic
inflammation and compromised bone health, but less is known about these linkages in …

A high-fat diet increases body weight and circulating estradiol concentrations but does not improve bone structural properties in ovariectomized mice

JJ Cao, BR Gregoire - Nutrition research, 2016 - Elsevier
Bone health is influenced by body mass and estrogen. The objective of the study was to
determine whether high-fat diet-induced obesity affects bone structure and alters markers of …

Anti-Menopausal Effects of Cornus officinalis and Ribes fasciculatum Extract In Vitro and In Vivo

E Park, E Lim, S Yeo, Y Yong, J Yang, SY Jeong - Nutrients, 2020 - mdpi.com
Natural herbal medicines have been developed for the treatment and prevention of women's
menopausal symptoms. In this study, we investigated the anti-menopausal effects of Cornus …

Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells

AL Strong, RS Hunter, RB Jones, AC Bowles… - Journal of Translational …, 2016 - Springer
Background Craniomaxillofacial defects secondary to trauma, tumor resection, or congenital
malformations are frequent unmet challenges, due to suboptimal alloplastic options and …

[HTML][HTML] A Review of Animal Models for Studying Bone Health in Type-2 Diabetes Mellitus (T2DM) and Obesity

SI Norazman, AS Mohd Zaffarin, AN Shuid… - International Journal of …, 2024 - mdpi.com
Preclinical research on diabetes and obesity has been carried out in various animal models
over the years. These animal models are developed from genetic manipulation that affects …

Cysteine prevents menopausal syndromes in ovariectomized mouse

NR Han, NR Kim, HM Kim… - Reproductive …, 2016 - journals.sagepub.com
Cysteine (Cys) is well known to be involved in oxidation–reduction reactions, serving as a
source of sulfides in the body. Amino acids are known to improve menopausal symptoms …

Effects of the Germinated Glycine max and Angelica gigas Nakai Mixture on Hepatic Lipid Metabolism and Bone Turnover Balance in Ovariectomized Rats

S Lee, Y Cho, J Choi, H Choi, TS Jung, J Kwon - Applied Sciences, 2023 - mdpi.com
Women going through menopause experience changes in their hormone levels, such as
decreased estrogen secretion. Those changes can lead to weight gain and steatosis (fatty …