As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better
understanding of the mechanisms underlying CVD is key for better management or …

Endothelial cells form a monolayer, which lines blood vessels. They are crucially involved in
maintaining blood fluidity and providing controlled vascular hemostasis at sites of injury …

Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of
blood glucose, is among the most common chronic diseases. The incidence and prevalence …

Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of
a broad spectrum of the most dreadful of human diseases, as endothelial cells have the key …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

The vasculature is an essential component of the circulatory system that plays a vital role in
the development, homeostasis, and disease of various organs in the human body. The …

Systemic blood pressure is acutely controlled by total peripheral resistance as determined
by the diameter of small arteries and arterioles, the contractility of which is regulated by …

Histological specimen and textbook schematics evoke static pictures of vascular networks.
However, the concept of a static system is grossly misleading as vessels and their …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …