Nonsense-mediated RNA decay: an emerging modulator of malignancy
K Tan, DG Stupack, MF Wilkinson - Nature Reviews Cancer, 2022 - nature.com
Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
To NMD or not to NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases
The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs
bearing premature termination codons (PTCs). Decades of work have elucidated the …
bearing premature termination codons (PTCs). Decades of work have elucidated the …
Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer
M Oka, L Xu, T Suzuki, T Yoshikawa, H Sakamoto… - Genome biology, 2021 - Springer
Background Long-read sequencing of full-length cDNAs enables the detection of structures
of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated …
of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated …
Exploiting tumor neoantigens to target cancer evolution: current challenges and promising therapeutic approaches
Immunotherapeutic manipulation of the antitumor immune response offers an attractive
strategy to target genomic instability in cancer. A subset of tumor-specific somatic mutations …
strategy to target genomic instability in cancer. A subset of tumor-specific somatic mutations …
The branched nature of the nonsense-mediated mRNA decay pathway
Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …
mechanism in all eukaryotes that regulates the expression of a significant fraction of both the …
Nonsense-Mediated mRNA Decay in Human Health and Diseases: Current Understanding, Regulatory Mechanisms and Future Perspectives
A Behera, GK Panigrahi, A Sahoo - Molecular Biotechnology, 2024 - Springer
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that is conserved
across all eukaryotes ensuring the quality of transcripts by targeting messenger RNA …
across all eukaryotes ensuring the quality of transcripts by targeting messenger RNA …
Targeting RNA exonuclease XRN1 potentiates efficacy of cancer immunotherapy
Despite the remarkable clinical responses achieved with immune checkpoint blockade
therapy, the response rate is relatively low and only a subset of patients can benefit from the …
therapy, the response rate is relatively low and only a subset of patients can benefit from the …
A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression
D Meraviglia-Crivelli, H Villanueva, AP Menon… - … Therapy-Nucleic Acids, 2022 - cell.com
Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome of many types
of aggressive tumors, but there still remain many cancer patients that do not respond to …
of aggressive tumors, but there still remain many cancer patients that do not respond to …
Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells
S Nasif, M Colombo, AC Uldry, MS Schröder… - NAR …, 2023 - academic.oup.com
Nonsense-mediated mRNA decay (NMD) is a eukaryotic RNA decay pathway with roles in
cellular stress responses, differentiation, and viral defense. It functions in both quality control …
cellular stress responses, differentiation, and viral defense. It functions in both quality control …