Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro

B Prasad, D Grimm, SM Strauch, GS Erzinger… - International journal of …, 2020 - mdpi.com
All life forms have evolved under the constant force of gravity on Earth and developed ways
to counterbalance acceleration load. In space, shear forces, buoyance-driven convection …

The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

[HTML][HTML] The impact of spaceflight and simulated microgravity on cell adhesion

X Lin, K Zhang, D Wei, Y Tian, Y Gao, Z Chen… - International Journal of …, 2020 - mdpi.com
Microgravity induces a number of significant physiological changes in the cardiovascular,
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …

Extraterrestrial gynecology: could spaceflight increase the risk of developing cancer in female astronauts? An updated review

R Drago-Ferrante, R Di Fiore, F Karouia… - International journal of …, 2022 - mdpi.com
Outer space is an extremely hostile environment for human life, with ionizing radiation from
galactic cosmic rays and microgravity posing the most significant hazards to the health of …

Microgravity effects on the matrisome

L Buravkova, I Larina, E Andreeva, A Grigoriev - Cells, 2021 - mdpi.com
Gravity is fundamental factor determining all processes of development and vital activity on
Earth. During evolution, a complex mechanism of response to gravity alterations was formed …

Breast cancer cells in microgravity: new aspects for cancer research

MZ Nassef, D Melnik, S Kopp, J Sahana… - International Journal of …, 2020 - mdpi.com
Breast cancer is the leading cause of cancer death in females. The incidence has risen
dramatically during recent decades. Dismissed as an “unsolved problem of the last century” …

Simulated microgravity influences VEGF, MAPK, and PAM signaling in prostate cancer cells

TE Hybel, D Dietrichs, J Sahana, TJ Corydon… - International Journal of …, 2020 - mdpi.com
Prostate cancer is one of the leading causes of cancer mortality in men worldwide. An
unusual but unique environment for studying tumor cell processes is provided by …

Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity

C Liu, G Zhong, Y Zhou, Y Yang, Y Tan, Y Li… - Cell …, 2020 - Wiley Online Library
Abstract Objectives Cardiac Ca2+ signalling plays an essential role in regulating excitation‐
contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to …

Testing Lab-on-a-Chip technology for culturing human melanoma cells under simulated microgravity

D Przystupski, A Górska, O Michel, A Podwin… - Cancers, 2021 - mdpi.com
Simple Summary The main aim of this study was to investigate whether all-glass Lab-on-a-
Chip (LOC) platforms can be applied to cancer cell research performed under simulated …