Methods to study adult hippocampal neurogenesis in humans and across the phylogeny

J Terreros‐Roncal, M Flor‐García… - …, 2023 - Wiley Online Library
The hippocampus hosts the continuous addition of new neurons throughout life—a
phenomenon named adult hippocampal neurogenesis (AHN). Here we revisit the …

Unsaturated fatty acids and their immunomodulatory properties

S Coniglio, M Shumskaya, E Vassiliou - Biology, 2023 - mdpi.com
Simple Summary Diet can influence human health in both positive and negative ways. Ω-3
polyunsaturated fatty acids have an overall positive effect on humans. The sources of these …

Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging

ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

Nordic diet and its benefits in neurological function: a systematic review of observational and intervention studies

RS Jafari, V Behrouz - Frontiers in Nutrition, 2023 - frontiersin.org
Introduction Neurological disorders have been considered the major contributors to global
long-term disability and lower quality of life. Lifestyle factors, such as dietary patterns, are …

SARS-CoV-2 infection dysregulates NAD metabolism

A Izadpanah, JC Mudd, JGN Garcia… - Frontiers in …, 2023 - frontiersin.org
Introduction Severe COVID-19 results initially in pulmonary infection and inflammation.
Symptoms can persist beyond the period of acute infection, and patients with Post-Acute …

The role of microRNAs in neurobiology and pathophysiology of the hippocampus

SK Rashidi, A Kalirad, S Rafie, E Behzad… - Frontiers in molecular …, 2023 - frontiersin.org
MicroRNAs (miRNAs) are short non-coding and well-conserved RNAs that are linked to
many aspects of development and disorders. MicroRNAs control the expression of genes …

Opportunities and challenges in targeting orphan nuclear receptors

L Isigkeit, D Merk - Chemical Communications, 2023 - pubs.rsc.org
Nuclear receptor modulation enables pharmacological control of gene expression thus
rendering the 48 human nuclear receptors as attractive targets for drug discovery. Several …

rTMS ameliorates depressive‐like behaviors and regulates the gut microbiome and medium‐and long‐chain fatty acids in mice exposed to chronic unpredictable mild …

CH Zhou, YH Chen, SS Xue, QQ Shi… - CNS Neuroscience …, 2023 - Wiley Online Library
Introduction Repetitive transcranial magnetic stimulation (rTMS) is a clinically useful therapy
for depression. However, the effects of rTMS on the metabolism of fatty acids (FAs) and the …

[HTML][HTML] Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice

S Aljuraysi, M Platt, M Pulix, H Poptani… - Neurobiology of Disease, 2024 - Elsevier
Mutations of the human TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9
(TRAPPC9) cause a neurodevelopmental disorder characterised by microcephaly and …

A clinically relevant dosage of mitoxantrone disrupts the glutathione and lipid metabolic pathways of the CD-1 mice brain: a metabolomics study

A Dias-Carvalho, A Margarida-Araújo… - International Journal of …, 2023 - mdpi.com
Long-term cognitive dysfunction, or “chemobrain”, has been observed in cancer patients
treated with chemotherapy. Mitoxantrone (MTX) is a topoisomerase II inhibitor that binds and …