The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

Metastasis contributes to the vast majority of cancer-related mortality. Regulatory
mechanisms of the multistep invasion-metastasis cascade are being unraveled. TP53 is the …

TP53 missense mutations dramatically influence tumor progression, however, their
mechanism of action is still poorly understood. Here we demonstrate the fundamental role of …

The tumor suppressor p53 is a central hub in a molecular network controlling cell
proliferation and death in response to potentially oncogenic conditions, and a wide array of …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

Three decades of p53 research have led to many advances in understanding the basic
biology of normal and cancer cells. Nonetheless, the detailed functions of p53 in normal …

Abstract NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell.
Here we show that in cancer cells NRF2 targets are selectively upregulated or repressed …

Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins
are getting an increased experimental support as active oncoproteins promoting tumor …

The p53 gene family members p53, p73, and p63 display several isoforms derived from the
presence of internal promoters and alternative splicing events. They are structural homologs …