Multidimensional progressive declines in the absence of standard biomarkers for neurodegeneration are observed commonly in the development of schizophrenia, and are …
Drug repositioning is a promising drug development technique to identify new indications for existing drugs. However, existing computational models only make use of lower-order …
Previous studies have observed a significant comorbidity between Alzheimer's disease (AD) and some other neuropsychiatric disorders. However, the mechanistic connections between …
K Runge, A Balla, BL Fiebich, SJ Maier… - Schizophrenia …, 2023 - academic.oup.com
Background Schizophrenia spectrum disorders (SSD) can be associated with neurodegenerative processes causing disruption of neuronal, synaptic, or axonal integrity …
DH Adamowicz, EE Lee - Current opinion in psychiatry, 2023 - journals.lww.com
Recent evidence supports accelerated cognitive decline and brain changes in middle-aged and older people with schizophrenia, relative to the general population. More research in …
J Wang, P Kochunov, H Sampath, KS Hatch… - Schizophrenia …, 2021 - Elsevier
We hypothesized that cerebral white matter deficits in schizophrenia (SZ) are driven in part by accelerated white matter aging and are associated with cognitive deficits. We used a …
Abstract Brodmann Area 46 (BA46) has long been regarded as a hotspot of disease pathology in individuals with schizophrenia (SCH) and major depressive disorder (MDD) …
Background Thalamocortical white matter connectivity is disrupted in psychosis and is hypothesized to play a role in its etiology and associated cognitive impairment. Attenuated …
Neuroimaging research has uncovered a multitude of neural abnormalities associated with psychopathology, but few prediction-based studies have been conducted during …