During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Research on the biological function of nuclear factor-κB (NF-κB), a key mediator of inducible
transcription in the immune system, has traditionally focused on its role in the initiation of …

Background Asthma in a mouse model spontaneously resolves after cessation of allergen
exposure. We developed a mouse model in which asthma features persisted for 6 months …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

Inflammation is a natural host defense mechanism that protects the body from pathogenic
microorganisms. A growing body of research suggests that inflammation is a key factor in …

Inflammation is an evolutionarily conserved host reaction that is initiated in response to
trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood …

Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular
processes including proliferation, differentiation, apoptosis, cell survival, cell motility …

Acute lung injury (ALI) is a severe clinical disease marked by dysregulated inflammation
response and has a high rate of morbidity and mortality. Macrophages, which play diverse …

Inflammation in the central nervous system (CNS) is a common feature of age-related
neurodegenerative diseases. Proinflammatory cytokines, such as IL-1β and TNFα, are …

Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …