Recent advances in ionic liquids in biomedicine

AM Curreri, S Mitragotri, EEL Tanner - Advanced Science, 2021 - Wiley Online Library
The use of ionic liquids and deep eutectic solvents in biomedical applications has grown
dramatically in recent years due to their unique properties and their inherent tunability. This …

Biological activity of ionic liquids and their application in pharmaceutics and medicine

KS Egorova, EG Gordeev, VP Ananikov - Chemical reviews, 2017 - ACS Publications
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

Protein stabilization and enzyme activation in ionic liquids: specific ion effects

H Zhao - Journal of Chemical Technology & Biotechnology, 2016 - Wiley Online Library
There are still debates on whether the hydration of ions perturbs the water structure, and
what is the degree of such disturbance; therefore, the origin of the Hofmeister effect on …

Do Ionic Liquids Exhibit the Required Characteristics to Dissolve, Extract, Stabilize, and Purify Proteins? Past-Present-Future Assessment

P Bharmoria, AA Tietze, D Mondal, TS Kang… - Chemical …, 2024 - ACS Publications
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …

Overview of the stability of α-chymotrypsin in different solvent media

A Kumar, P Venkatesu - Chemical Reviews, 2012 - ACS Publications
1. INTRODUCTION The ability of amino acids to form a three-dimensional (3D) protein
structure is significantly interesting because it combines the aspects of biophysical …

Room temperature ionic liquids meet biomolecules: a microscopic view of structure and dynamics

A Benedetto, P Ballone - ACS Sustainable Chemistry & …, 2016 - ACS Publications
Room temperature ionic liquids (RTILs) and biomolecules are both paradigmatic classes of
organic molecules, each consisting of a prodigious number of distinct chemical species …

Biocompatibility of ionic liquids towards protein stability: A comprehensive overview on the current understanding and their implications

A Kumar, M Bisht, P Venkatesu - International journal of biological …, 2017 - Elsevier
Over the past years since the discovery of ionic liquids (ILs), there is an increased demand
to consider ILs as novel biocompatible co-solvents for proteins. Due to their tunable physical …

Aqueous ionic liquids and their effects on protein structures: an overview on recent theoretical and experimental results

J Smiatek - Journal of Physics: Condensed Matter, 2017 - iopscience.iop.org
Ionic liquids (ILs) are used in a variety of technological and biological applications. Recent
experimental and simulation results reveal the influence of aqueous ionic liquids on the …

Does the stability of proteins in ionic liquids obey the Hofmeister series?

A Kumar, P Venkatesu - International journal of biological macromolecules, 2014 - Elsevier
Understanding the behavior of Hofmeister anions of ionic liquids (ILs) on protein stability
helps to shed light on how the anions interact with proteins in aqueous solution and is a long …

Cholinium-based ionic liquids as efficient media for improving the structural and thermal stability of immunoglobulin G antibodies

D Dhiman, M Bisht, APM Tavares… - ACS Sustainable …, 2022 - ACS Publications
Among antibody-based biopharmaceuticals, immunoglobulin G (IgG) plays a central role.
However, IgG is a protein and as such easily loses stability, thus compromising its use as an …