The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases

M Piotrowska, M Swierczynski, J Fichna… - Pharmacological …, 2021 - Elsevier
Abstract Nrf2 (nuclear factor erythroid 2-related factor 2) is a stress-responsive transcription
factor, associated with cellular homeostasis. Under normal conditions Nrf2 is kept in the …

Treatment effects of natural products on inflammatory bowel disease in vivo and their mechanisms: Based on animal experiments

Y Zhou, D Wang, W Yan - Nutrients, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the
intestine that can be classified as ulcerative colitis (UC) and Crohn's disease (CD) …

Caffeic acid supplement alleviates colonic inflammation and oxidative stress potentially through improved gut microbiota community in mice

F Wan, R Zhong, M Wang, Y Zhou, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Caffeic acid (CA) is one of the major phenolic acids of coffee with multiple biological
activities. Our previous study found that 500 mg/kg of chlorogenic acid (CGA) had the …

Anti‐Inflammatory, Antioxidant, and Healing‐Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats

MA Naini, A Zargari-Samadnejad… - Evidence‐Based …, 2021 - Wiley Online Library
Background. Ulcerative colitis is a worldwide chronic gastrointestinal disease characterized
by variable extensions of colon mucosal inflammation. The available drugs have an …

Mechanism and impact of heavy metal-aluminum (Al) toxicity on male reproduction: Therapeutic approaches with some phytochemicals

FEM Ali, KSA Badran, MA Baraka, HS Althagafy… - Life Sciences, 2024 - Elsevier
Heavy metals are ubiquitous environmental toxicants that have been known to have a
serious effect on human and animal health. Aluminum (Al) is a widely distributed metal in …

Bovine lactoferrin protects dextran sulfate sodium salt mice against inflammation and impairment of colonic epithelial barrier by regulating gut microbial structure and …

S Wang, J Zhou, D Xiao, G Shu, L Gu - Frontiers in Nutrition, 2021 - frontiersin.org
Background: Ulcerative colitis is characterized by relapsing and remitting mucosal
inflammation. Bovine lactoferrin (BL) is a multifunctional protein that could regulate the …

The protective effect of esculetin against aluminium chloride‐induced reproductive toxicity in rats

E Türk, I Ozan Tekeli, H Özkan, A Uyar, M Cellat… - Andrologia, 2021 - Wiley Online Library
One of the prominent health problems caused by Aluminium was the decrease in male
fertility rates. In the study, the protective effect of Esculetin (ESC) against the reproductive …

Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

M Cellat, M Kuzu, CT İşler, M Etyemez… - Naunyn-Schmiedeberg's …, 2021 - Springer
Asthma is an inflammatory disease that affects many people around the world, especially
persons at paediatric age group. The effectiveness of tyrosol, a natural phenolic compound …

Oral intake of titanium dioxide nanoparticles affect the course and prognosis of ulcerative colitis in mice: involvement of the ROS-TXNIP-NLRP3 inflammasome …

S Duan, H Wang, Y Gao, X Wang, L Lyu… - Particle and Fibre …, 2023 - Springer
Abstract Background Titanium dioxide (TiO2), no matter in nanoscale or micron sizes, has
been widely used in food industry as additives for decades. Given the potential impact of …

Propofol regulates the TLR4/NF-κB pathway through miRNA-155 to protect colorectal cancer intestinal barrier

Y Gao, T Han, C Han, H Sun, X Yang, D Zhang, X Ni - Inflammation, 2021 - Springer
Surgery for colorectal cancer (CRC) can cause damage to the intestinal mucosal barrier and
lead to bacterial invasion. This study mainly analyzed whether propofol (PPF) could protect …