Long-term survival after kidney transplantation

S Hariharan, AK Israni… - New England Journal of …, 2021 - Mass Medical Soc
Long-Term Survival after Kidney Transplantation This review discusses demographics,
survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative …

Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response

H Wu, AF Malone, EL Donnelly, Y Kirita… - Journal of the …, 2018 - journals.lww.com
Background Single-cell genomics techniques are revolutionizing our ability to characterize
complex tissues. By contrast, the techniques used to analyze renal biopsy specimens have …

[HTML][HTML] Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion

J Liu, S Kumar, E Dolzhenko, GF Alvarado, J Guo… - JCI insight, 2017 - ncbi.nlm.nih.gov
Though an acute kidney injury (AKI) episode is associated with an increased risk of chronic
kidney disease (CKD), the mechanisms determining the transition from acute to irreversible …

HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

M Chen, MC Menon, W Wang, J Fu, Z Yi, Z Sun… - Nature …, 2023 - nature.com
Renal inflammation and fibrosis are the common pathways leading to progressive chronic
kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as …

[HTML][HTML] Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation–Consensus for the Banff Human Organ Transplant (B-HOT) gene panel and …

M Mengel, A Loupy, M Haas, C Roufosse… - American Journal of …, 2020 - Elsevier
This meeting report from the XV Banff conference describes the creation of a multiorgan
transplant gene panel by the Banff Molecular Diagnostics Working Group (MDWG). This …

Tackling chronic kidney transplant rejection: challenges and promises

X Lai, X Zheng, JM Mathew, L Gallon… - Frontiers in …, 2021 - frontiersin.org
Despite advances in post-transplant management, the long-term survival rate of kidney
grafts and patients has not improved as approximately forty percent of transplants fails within …

The molecular phenotype of kidney transplants: insights from the MMDx project

PF Halloran, KS Madill-Thomsen, J Reeve - Transplantation, 2024 - journals.lww.com
This review outlines the molecular disease states in kidney transplant biopsies as
documented in the development of the Molecular Microscope Diagnostic System (MMDx) …

[HTML][HTML] Diagnosis of renal transplant rejection: Banff classification and beyond

HJ Jeong - Kidney research and clinical practice, 2020 - ncbi.nlm.nih.gov
Diagnosis of renal transplant rejection is dependent on interpretation of renal allograft
biopsies. The Banff Classification of Allograft Pathology, which was developed as a …

[HTML][HTML] Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies

K Madill-Thomsen, A Perkowska-Ptasińska… - American Journal of …, 2020 - Elsevier
Discrepancy analysis comparing two diagnostic platforms offers potential insights into both
without assuming either is always correct. Having optimized the Molecular Microscope …

[HTML][HTML] The causes, significance and consequences of inflammatory fibrosis in kidney transplantation: the Banff i-IFTA lesion

BJ Nankivell, M Shingde, KL Keung, CLS Fung… - American journal of …, 2018 - Elsevier
Inflammation within areas of interstitial fibrosis and tubular atrophy (i-IFTA) is associated with
adverse outcomes in kidney transplantation. We evaluated i-IFTA in 429 indication-and …