HPV-driven oncogenesis—much more than the E6 and E7 oncoproteins

J Janiszewska, M Kostrzewska-Poczekaj… - Journal of Applied …, 2024 - Springer
High-risk human papillomaviruses are well-established drivers of several cancer types
including cervical, head and neck, penile as well as anal cancers. While the E6 and E7 viral …

Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma

C Palumbo, M Benvenuto, C Focaccetti… - Frontiers in …, 2023 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type,
has often an aggressive course and is poorly responsive to current therapeutic approaches …

PI3K/AKT/mTOR signaling pathway in HPV-driven head and neck carcinogenesis: therapeutic implications

F Aguayo, F Perez-Dominguez, JC Osorio, C Oliva… - Biology, 2023 - mdpi.com
Simple Summary A subgroup of cancers that arises in the zone of the head and neck
(HNCs) are caused by some types of human papillomavirus (HPV), so called high-risk (HR) …

Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV600E

FF Hagar, SH Abbas, HAM Gomaa, BGM Youssif… - BMC chemistry, 2023 - Springer
Introduction One of the most robust global challenges and difficulties in the 21st century is
cancer. Treating cancer is a goal which continues to motivate researchers to innovate in …

Cancer cell metabolism reprogramming and its potential implications on therapy in squamous cell carcinoma of the head and neck: A review

F Perri, G Della Vittoria Scarpati, M Pontone… - Cancers, 2022 - mdpi.com
Simple Summary Metabolic reprogramming is a common phenomenon occurring in several
solid tumors, among which are head and neck cancers, which allows them to better survive …

[HTML][HTML] The role of the PI3K/Akt/mTOR Axis in Head and Neck squamous cell carcinoma

Q Jiang, J Xiao, YC Hsieh, NL Kumar, L Han, Y Zou… - Biomedicines, 2024 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is one of the most common
malignancies globally, representing a significant public health problem with a poor …

APOBEC3B is overexpressed in cervical cancer and promotes the proliferation of cervical cancer cells through apoptosis, cell cycle, and p53 pathway

Z Wei, J Gan, X Feng, M Zhang, Z Chen, H Zhao… - Frontiers in …, 2022 - frontiersin.org
Objective APOBEC3B (A3B), a member of the APOBEC family of cytidine deaminases, has
been gradually regarded as a key cancerous regulator. However, its expression and …

Multi-region sequencing depicts intratumor heterogeneity and clonal evolution in cervical cancer

C Wang, R Bai, Y Liu, K Wang, Y Wang, J Yang, H Cai… - Medical Oncology, 2023 - Springer
Cervical cancer is a heterogeneous malignancy mainly caused by human papillomavirus
(HPV). While a few studies have revealed heterogeneity of cervical cancer in chromosome …

Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling …

A Iranpanah, MB Majnooni, H Biganeh… - Phytotherapy …, 2024 - Wiley Online Library
Recently, malignant neoplasms have growingly caused human morbidity and mortality.
Head and neck cancer (HNC) constitutes a substantial group of malignancies occurring in …

Diagnostics of HNSCC patients: an analysis of cell lines and patient-derived xenograft models for personalized Therapeutical Medicine

RG Ursu, I Luchian, C Damian, E Porumb-Andrese… - Diagnostics, 2022 - mdpi.com
Head and neck squamous cell carcinomas (HNSCC) are very frequent worldwide, and
smoking and chronic alcohol use are recognized as the main risk factors. For oropharyngeal …