New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

W Deng, JB Aimone, FH Gage - Nature reviews neuroscience, 2010 - nature.com
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an
important role for adult hippocampal neurogenesis in learning and memory, but its specific …

Physical exercise induces hippocampal neurogenesis and prevents cognitive decline

CL Ma, XT Ma, JJ Wang, H Liu, YF Chen… - Behavioural brain …, 2017 - Elsevier
Accumulating evidence from animal and human research indicate that adult hippocampal
neurogenesis plays a key role in cognition. Meanwhile, cognitive decline is well known to …

N, N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

JA Morales-Garcia, J Calleja-Conde… - Translational …, 2020 - nature.com
Abstract N, N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally
used for ritual and therapeutic purposes across several South American countries. Here, we …

[HTML][HTML] COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis

R Klein, A Soung, C Sissoko, A Nordvig, P Canoll… - Research …, 2021 - ncbi.nlm.nih.gov
Abstract Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is associated with onset of neurological and psychiatric symptoms during and after the …

Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory

SSD Stone, CM Teixeira, LM DeVito… - Journal of …, 2011 - Soc Neuroscience
Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of
movement disorders and an emerging therapeutic approach for the treatment of disorders of …

When neurogenesis encounters aging and disease

O Lazarov, MP Mattson, DA Peterson… - Trends in …, 2010 - cell.com
In this review, we consider the evidence that a reduction in neurogenesis underlies aging-
related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD) …

Adult‐born hippocampal neurons promote cognitive flexibility in mice

NS Burghardt, EH Park, R Hen, AA Fenton - Hippocampus, 2012 - Wiley Online Library
The hippocampus is involved in segregating memories, an ability that utilizes the neural
process of pattern separation and allows for cognitive flexibility. We evaluated a proposed …

Adult hippocampal neurogenesis, fear generalization, and stress

A Besnard, A Sahay - Neuropsychopharmacology, 2016 - nature.com
The generalization of fear is an adaptive, behavioral, and physiological response to the
likelihood of threat in the environment. In contrast, the overgeneralization of fear, a cardinal …

Neurogenesis and Alzheimer's disease: at the crossroads

O Lazarov, RA Marr - Experimental neurology, 2010 - Elsevier
While a massive and progressive neuronal loss in specific areas such as the hippocampus
and cortex unequivocally underlies cognitive deterioration and memory loss in Alzheimer's …

[HTML][HTML] Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells

SG Temprana, LA Mongiat, SM Yang, MF Trinchero… - Neuron, 2015 - cell.com
Developing granule cells (GCs) of the adult dentate gyrus undergo a critical period of
enhanced activity and synaptic plasticity before becoming mature. The impact of developing …