In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

The interactions between cancer cells and their micro-and macroenvironment create a
context that promotes tumour growth and protects it from immune attack. The functional …

We review the role of cadherins and cadherin-related proteins in human cancer. Cellular
and animal models for human cancer are also dealt with whenever appropriate. E-cadherin …

Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs),
early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC …

The gene-expression profile of aggressive cutaneous and uveal melanoma cells resembles
that of an undifferentiated, embryonic-like cell. The plasticity of certain types of cancer cell …

Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and
mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of …

Low-molecular-weight vascular-disrupting agents (VDAs) cause a pronounced shutdown in
blood flow to solid tumours, resulting in extensive tumour-cell necrosis, while they leave the …

Tumour blood vessels express markers that are not present in resting blood vessels of
normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions …

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions.
These junctional complexes are related to those found at epithelial junctions but with …