With the development of modern chemistry and biology, non-proteinogenic amino acids
(NPAAs) have become a powerful tool for developing peptide-based drug candidates. Drug …

The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the
addition of approximately 70 unnatural amino acids (UAAs) to the genetic codes of …

Highlights•Naturally occurring peptides are important resources in order to develop
pharmaceutical lead compounds.•Natural peptides are often limited by poor stability or …

In vitro display technologies, best exemplified by phage and yeast display, were first
described for the selection of antibodies some 20 years ago. Since then, many antibodies …

The ability to genetically encode unnatural amino acids beyond the common 20 has allowed
unprecedented control over the chemical structures of recombinantly expressed proteins …

Over the past two decades, genetic code expansion (GCE)-enabled methods for
incorporating noncanonical amino acids (ncAAs) into proteins have significantly advanced …

Prostate specific membrane antigen (PSMA) is a membrane-bound glutamate
carboxypeptidase overexpressed in many forms of prostate cancer. Our laboratory has …

Antibody conjugates are important in many areas of medicine and biological research, and
antibody–drug conjugates (ADCs) are becoming an important next generation class of …

Synthetic immunology, the development of synthetic systems capable of modulating and/or
manipulating immunological functions, represents an emerging field of research with …

Nanobodies (Nb) have a promising future as a part of next generation chemodrug delivery
systems. Nb, or VHH, are small (15 kDa) monomeric antibody fragments consisting of the …