Factor XI inhibitors: cardiovascular perspectives

R De Caterina, D Prisco… - European Heart …, 2023 - academic.oup.com
Anticoagulants are the cornerstone for prevention and treatment of thrombosis but are not
completely effective, and concerns about the risk of bleeding continue to limit their uptake …

[HTML][HTML] Coagulome and the tumor microenvironment: an actionable interplay

A Galmiche, J Rak, LT Roumenina, Z Saidak - Trends in Cancer, 2022 - cell.com
Human tumors often trigger a hypercoagulable state that promotes hemostatic
complications, including venous thromboembolism. The recent application of systems …

The role of coagulome in the tumor immune microenvironment

R Wahab, MM Hasan, Z Azam, PJ Grippo… - Advanced drug delivery …, 2023 - Elsevier
The rising incidence and persistent thrombosis in multiple cancers including those that are
immunosuppressive highlight the need for understanding the tumor coagulome system and …

[HTML][HTML] Low dose apixaban as secondary prophylaxis of venous thromboembolism in cancer patients–30 months follow‐up

TL Larsen, H Garresori, J Brekke, T Enden… - Journal of Thrombosis …, 2022 - Elsevier
Background There are no data on the effect of low‐dose anticoagulation as secondary
prophylaxis for venous thromboembolism (VTE) in cancer patients. We assessed the efficacy …

Haemostatic alterations in patients with cirrhosis and hepatocellular carcinoma: laboratory evidence and clinical implications

A Zanetto, E Campello, F Pelizzaro, F Farinati… - Liver …, 2022 - Wiley Online Library
Venous thrombosis is a frequent complication in cancer and is associated with high
morbidity and mortality. Hepatocellular carcinoma (HCC) is the most common primary liver …

[HTML][HTML] Platelet-Derived PDGFB promotes recruitment of cancer-associated fibroblasts, deposition of extracellular matrix and Tgfβ signaling in the tumor …

Y Zhang, E Manouchehri Doulabi, M Herre, J Cedervall… - Cancers, 2022 - mdpi.com
Simple Summary The aim of this study was to investigate the relative contribution of PDGFB
derived specifically from platelets to the remodeling of the extracellular matrix (ECM) in …

Survival implications of thrombus recurrence or bleeding in cancer patients receiving anticoagulation for venous thromboembolism treatment

RD McBane II, DT Vlazny, D Houghton… - Thrombosis and …, 2023 - thieme-connect.com
Background Study aims were to analyze prospectively collected data from patients with
cancer-associated venous thromboembolism (VTE) to determine the impact of VTE …

[HTML][HTML] Patient-related factors predicting stent thrombosis in percutaneous coronary interventions

L Anghel, BS Tudurachi, A Tudurachi, A Zăvoi… - Journal of Clinical …, 2023 - mdpi.com
Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy
have significantly improved, particularly with the advent of the drug-eluting stent (DES). First …

Thrombosis in acute myeloid leukemia: pathogenesis, risk factors and therapeutic challenges

M Olivi, F Di Biase, G Lanzarone, G Arrigo… - … Treatment Options in …, 2023 - Springer
Opinion statement Prophylaxis and treatment of thrombosis in leukemic patients still
represent a major challenge with several clinical questions yet to be solved. Indeed, the …

[HTML][HTML] Heparin and derivatives for advanced cell therapies

S Laner-Plamberger, M Oeller, E Rohde… - International Journal of …, 2021 - mdpi.com
Heparin and its derivatives are saving thousands of human lives annually, by successfully
preventing and treating thromboembolic events. Although the mode of action during …