Cancer diagnosis based on gene expression profile data has attracted extensive attention in
computational biology and medicine. It suffers from three challenges in practical …

Simple Summary Ampullary tumors are rare malignancies of the upper gastrointestinal tract.
Histologic, immunohistochemical and, most recently, genomic biomarkers have been used …

Purpose: The clinical behavior of ampullary adenocarcinoma varies widely. Targeted tumor
sequencing may better define biologically distinct subtypes to improve diagnosis and …

The vast preponderance of somatic mutations in a typical cancer are either extremely rare or
have never been previously recorded in available databases that track somatic mutations …

Importance Ampullary adenocarcinoma (AA) is characterized by clinical and genomic
heterogeneity. A previously developed genomic classifier defined biologically distinct …

A large and growing body of research has documented strong links between somatic
mutations and different cancer types. This has put forward an emerging field aiming to …

Inferring the cancer-type specificities of ultra-rare, genome-wide somatic mutations is an
open problem. Traditional statistical methods cannot handle such data due to their ultra-high …

Numerous studies over the past generation have identified germline variants that increase
specific cancer risks. Simultaneously, a revolution in sequencing technology has permitted …

Many studies have shown that the distributions of the genomic, nucleotide, and epigenetic
contexts of somatic variants in tumors are informative of cancer etiology. Recently, a new …

Sažetak Identifying the cell-of-origin (COO) for tumors of unknown primary site is crucial for
selecting effective therapies, but the heterogeneity and unique genomic profiles of these …