Metabolic engineering of the shikimate pathway for production of aromatics and derived compounds—present and future strain construction strategies

NJH Averesch, JO Krömer - Frontiers in Bioengineering and …, 2018 - frontiersin.org
The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential
bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced …

Flavonoid production: current trends in plant metabolic engineering and de novo microbial production

H Tariq, S Asif, A Andleeb, C Hano, BH Abbasi - Metabolites, 2023 - mdpi.com
Flavonoids are secondary metabolites that represent a heterogeneous family of plant
polyphenolic compounds. Recent research has determined that the health benefits of fruits …

Building microbial factories for the production of aromatic amino acid pathway derivatives: from commodity chemicals to plant-sourced natural products

M Cao, M Gao, M Suastegui, Y Mei, Z Shao - Metabolic engineering, 2020 - Elsevier
The aromatic amino acid biosynthesis pathway, together with its downstream branches,
represents one of the most commercially valuable biosynthetic pathways, producing a …

[HTML][HTML] Metabolic engineering and synthetic biology of plant natural products–A minireview

AS Birchfield, CA McIntosh - Current Plant Biology, 2020 - Elsevier
Plant natural products include a diverse array of compounds that play important roles in
plant metabolism and physiology. After elucidation of biosynthetic pathways and regulatory …

Recent trends in metabolic engineering of microbial chemical factories

Y Liu, J Nielsen - Current opinion in biotechnology, 2019 - Elsevier
Highlights•Microbial cell factories can be tailored for producing certain 'drop-in'chemicals.•
Metabolic engineering has greatly enhanced the development of microbial cell …

Fermentative production of Vitamin E tocotrienols in Saccharomyces cerevisiae under cold-shock-triggered temperature control

B Shen, P Zhou, X Jiao, Z Yao, L Ye, H Yu - Nature communications, 2020 - nature.com
The diverse physiological functions of tocotrienols have listed them as valuable
supplementations to α-tocopherol-dominated Vitamin E products. To make tocotrienols more …

Construction of an l-Tyrosine Chassis in Pichia pastoris Enhances Aromatic Secondary Metabolite Production from Glycerol

R Kumokita, T Bamba, K Inokuma, T Yoshida… - ACS Synthetic …, 2022 - ACS Publications
Bioactive plant-based secondary metabolites such as stilbenoids, flavonoids, and
benzylisoquinoline alkaloids (BIAs) are produced from l-tyrosine (l-Tyr) and have a wide …

Multi‐modular engineering of Saccharomyces cerevisiae for high‐titre production of tyrosol and salidroside

H Liu, Y Tian, Y Zhou, Y Kan, T Wu… - Microbial …, 2021 - Wiley Online Library
Tyrosol and its glycosylated product salidroside are important ingredients in
pharmaceuticals, nutraceuticals and cosmetics. Despite the ability of Saccharomyces …

Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production

M Gao, Y Zhao, Z Yao, Q Su, P Van Beek… - Nature …, 2023 - nature.com
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with
broad applications. Here, we present the development of a yeast consortium for efficient …

Advances in 2-phenylethanol production from engineered microorganisms

Y Wang, H Zhang, X Lu, H Zong, B Zhuge - Biotechnology Advances, 2019 - Elsevier
Phenylethanol (2-PE) is an important flavor ingredient with a rose-like odor. Due to concerns
about the toxic byproducts potentially found in 2-PE from chemical synthesis, consumers …