The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al …

Neuronal subtype specification in the vertebrate neural tube is one of the best-studied
examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a …

During mammalian tooth development, the oral ectoderm and mesenchyme coordinate their
growth and differentiation to give rise to organs with precise shapes, sizes and functions …

The Shh signaling pathway is required in many mammalian tissues for embryonic
patterning, cell proliferation and differentiation. In addition, inappropriate activation of the …

Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily
conserved, recent studies indicate that fundamental differences exist between Drosophila …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

Abstract Approximately 1,000,000 epithelial skin cancers are diagnosed in the United States
each year and most are basal cell carcinomas (BCCs). The pathogenesis of these tumours …

The specification of neuronal fates in the ventral spinal cord depends on the regulation of
homeodomain (HD) and basic-helix-loop-helix (bHLH) proteins by Sonic hedgehog (Shh) …

The mouse open brain (opb) and Sonic hedgehog (Shh) genes have opposing roles in
neural patterning: opb is required for dorsal cell types and Shh is required for ventral cell …