Retinal degenerations are a heterogeneous group of diseases characterized by death of
photoreceptors and progressive loss of vision. Retinal degenerations are a major cause of …

To understand how the brain relates to behavior, it is essential to record neural activity in
awake, behaving animals. To achieve this goal, a large variety of genetically encoded …

Brain activity and connectivity alter drastically during epileptic seizures. The brain networks
shift from a balanced resting state to a hyperactive and hypersynchronous state. It is …

Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …

Drug discovery and development for Alzheimer's disease (AD) are complex and challenging
due to the higher failure rate in the drug development process. The overproduction and …

Genetically-encoded fluorescent sensors have been actively developed over the last few
decades and used in live imaging and drug screening. Real-time monitoring of drug action …

Glutamate is the major fast excitatory neurotransmitter in the nervous system, and
researchers have for decades pursued tools for monitoring glutamate release in real time …

Glutamate transporter proteins, expressed on both neurons and glia, serve as the main
gatekeepers that dictate the spatial and temporal actions of extracellular glutamate …

Myelination is crucial for the development and maintenance of axonal integrity, especially
fast axonal action potential conduction. There is increasing evidence that glutamate …

The zebrafish (Danio rerio) possesses a vertebrate-type retina that is extraordinarily
conserved in evolution. This well-organized and anatomically easily accessible part of the …