Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics

R Yahyapour, E Motevaseli, A Rezaeyan… - Clinical and …, 2018 - Springer
Every year, millions of cancer patients undergo radiation therapy for treating and destroying
abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation …

Antioxidant properties of probiotics and their protective effects in the pathogenesis of radiation-induced enteritis and colitis

BG Spyropoulos, EP Misiakos, C Fotiadis… - Digestive diseases and …, 2011 - Springer
Radiation therapy has become one of the most important treatment modalities for human
malignancy, but certain immediate and delayed side-effects on the normal surrounding …

Targeting of cellular redox metabolism for mitigation of radiation injury

B Farhood, M Ashrafizadeh, M Hoseini-Ghahfarokhi… - Life sciences, 2020 - Elsevier
Accidental exposure to ionizing radiation is a serious concern to human life. Studies on the
mitigation of side effects following exposure to accidental radiation events are ongoing …

The effect of selenium and/or vitamin E treatments on radiation—induced intestinal injury in rats

Ü Mutlu-Türkoǧlu, Y Erbil, S Öztezcan, V Olgaç… - Life Sciences, 2000 - Elsevier
Cytotoxic effects of ionizing radiation on gastrointestinal epithelium may be related to
oxidative stress. In this study, we wanted to investigate the effects of selenium, vitamin E and …

Protective effect of melatonin against radiotherapy-induced small intestinal oxidative stress: biochemical evaluation

AE Musa, D Shabeeb, HSQ Alhilfi - Medicina, 2019 - mdpi.com
Background and Objectives: Radiation enteritis is a common side effect after radiotherapy
for abdominal and pelvic malignancies. The aim of the present study was to investigate the …

The effect of glutamine on radiation-induced organ damage

Y Erbil, S Öztezcan, U Barbaros, V Olgaç, H Bilge… - Life sciences, 2005 - Elsevier
Radiation enteritis is a significant clinical problem in patients receiving ionizing radiation
directed to the abdomen or pelvis. Although radiation is aimed to be directed against the …

The effect of heme oxygenase-1 induction by glutamine on radiation-induced intestinal damage: the effect of heme oxygenase-1 on radiation enteritis

Y Erbil, S Öztezcan, V Olgaç, U Barbaros… - The American journal of …, 2006 - Elsevier
BACKGROUND: Radiation enteritis is a significant clinical problem in patients receiving
ionizing radiation directed at the abdomen or pelvis. The small intestine is the most …

The protective effects of apocynin on ionizing radiation-induced intestinal damage in rats

YF Cagin, H Parlakpinar, A Polat, N Vardi… - Drug Development …, 2016 - Taylor & Francis
Background and aims: Radiation colitis typically emerges during radiotherapy of intra-
abdominal malignancies. While the underlying mechanism remains unclear, it is considered …

Rheinic acid ameliorates radiation-induced acute enteritis in rats through PPAR-γ/NF-κB

H Sha, Y Gu, W Shen, L Zhang, F Qian, Y Zhao, H Li… - Genes & genomics, 2019 - Springer
Background Acute radiation enteritis (ARE), a common complication of intestinal caused by
abdominal and pelvic radiation therapy. Rheinic acid is a major active ingredient derived …

The role of nitric oxide in radiation damage

S Ohta, S Matsuda, M Gunji… - Biological and …, 2007 - jstage.jst.go.jp
MATERIALS AND METHODS Laboratory Animals Five-week-old male ICR strain mice
(Charles River Japan, Inc., Yokohama, Japan) were given nutritional chow (MF; Oriental …