Studies have identified demographic, clinical, psychosocial, and perioperative variables
associated with persistent pain after a variety of surgeries. This study aimed to perform a …

Opioid-induced hyperalgesia (OIH) occurs when opioids paradoxically enhance the pain
they are prescribed to ameliorate. To address a lack of perioperative awareness, we present …

Objectives: While opioids temporarily alleviate pain, the overshoot of balancing pain drivers
may increase pain, leading to opioid induced hyperalgesia (OIH). Our goal was to find out …

Opioid-induced hyperalgesia (OIH) is a paradoxical effect of opioids that is not consensually
recognized in clinical settings. We conducted a revision of clinical and preclinical studies …

Postoperative pain is prevalent and often undertreated. There is a risk that untreated or
suboptimally treated postoperative pain may transition into chronic postoperative pain …

Oxycodone is the most prescribed opioid for pain management and has been available in
clinics for almost a century, but effects of chronic oxycodone have been studied less than …

Introduction Acute pain episodes, also known as vaso-occlusive crises (VOC), are a major
symptom of sickle cell disease (SCD) and lead to frequent hospitalizations. The diagnosis of …

Objectives: To identify factors associated with the development of prolonged pain after hip
fracture surgery. Design: Secondary analysis of a randomized controlled trial. Setting: Eighty …

Pain management in patients on chronic opioid therapy is a common clinical challenge. The
phenomena of opioid-induced hyperalgesia and tolerance are important contributors to that …

Opioid-induced hyperalgesia (OIH) is characterized by a paradoxical increase in pain
sensitivity following opioid exposure. Although animal models indicate that …