An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …

Proteomics and metabolomics are two emerging fields that hold promise to shine light on the
molecular mechanisms causing neurodegenerative diseases. Research in this area may …

Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43
inclusions as a major pathological hallmark. Using a Drosophila model of TDP-43 …

The human microbiota is believed to influence health. Microbiome dysbiosis may be linked
to neurological conditions like Alzheimer's disease, amyotrophic lateral sclerosis, and …

The brain is vulnerable to different types of stresses, particularly oxidative stress as a result
of oxygen requirements/utilization in the body. Large amounts of unsaturated fatty acids …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease lacking effective
treatments. This is due, in part, to a complex and incompletely understood pathophysiology …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
selective degeneration of upper and lower motor neurons and by the progressive weakness …

Mitochondrial defects result in dysregulation of metabolomics and energy homeostasis that
are detected in upper motor neurons (UMNs) with TDP-43 pathology, a pathology that is …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor
neurons, leading to muscle weakness, paralysis, and eventual death. Research from the …

Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …