RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy

A Sheikh, S Md, P Kesharwani - Journal of Controlled Release, 2021 - Elsevier
A bird's eye view is now demanded in the area of cancer research to suppress the suffering
of cancer patient and mediate the lack of treatment related to chemotherapy. Chemotherapy …

Targeted delivery methods for anticancer drugs

VV Veselov, AE Nosyrev, L Jicsinszky, RN Alyautdin… - Cancers, 2022 - mdpi.com
Simple Summary The current main technological strategies for the delivery of anticancer
drugs are discussed herein. This comprehensive review may help researchers design …

Inflammation‐Regulated Auto Aggregated Hydrogel Microspheres Via Anchoring Cartilage Deep Matrix for Genes Delivery

L Chen, J Zhang, J Wang, J Lin… - Advanced Functional …, 2023 - Wiley Online Library
The high density structure of cartilage matrix negative charge seriously hinders the
penetration and enrichment of drugs/genes into cartilage tissue. In this study …

Safety challenges and application strategies for the use of dendrimers in medicine

X Li, A Naeem, S Xiao, L Hu, J Zhang, Q Zheng - Pharmaceutics, 2022 - mdpi.com
Dendrimers are used for a variety of applications in medicine but, due to their host–guest
and entrapment characteristics, are particularly used for the delivery of genes and drugs …

Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs

S Mignani, X Shi, A Karpus, JP Majoral - European journal of medicinal …, 2021 - Elsevier
There are several routes of administration to the brain, including intraparenchymal,
intraventricular, and subarachnoid injections. The blood-brain barrier (BBB) impedes the …

Polymeric dendrimers as nanocarrier vectors for neurotheranostics

H Li, S Zha, H Li, H Liu, KL Wong, AH All - Small, 2022 - Wiley Online Library
Dendrimers are polymers with well‐defined 3D branched structures that are vastly utilized in
various neurotheranostics and biomedical applications, particularly as nanocarrier vectors …

Dendrimers based cancer nanotheranostics: An overview

V Saluja, Y Mishra, V Mishra, N Giri, P Nayak - International Journal of …, 2021 - Elsevier
Cancer is a known deadliest disease that requires a judicious diagnostic, targeting, and
treatment strategy for an early prognosis and selective therapy. The major pitfalls of the …

Dendrimers toward translational nanotherapeutics: concise key step analysis

S Mignani, X Shi, J Rodrigues, R Roy… - Bioconjugate …, 2020 - ACS Publications
The goal of nanomedicine is to address specific clinical problems optimally, to fight human
diseases, and to find clinical relevance to change clinical practice. Nanomedicine is poised …

Engineered fluorescent carbon dots and G4-G6 PAMAM dendrimer nanohybrids for bioimaging and gene delivery

I Martins, H Tomás, F Lahoz, J Rodrigues - Biomacromolecules, 2021 - ACS Publications
Carbon dots (CDs) and G4-G6 (polyamidoamine) PAMAM-NH2 dendrimers were self-
assembled to produce CDs@ PAMAM nanohybrids for transfection and bioimaging …

Brain delivery of biomimetic phosphorus dendrimer/antibody nanocomplexes for enhanced glioma immunotherapy via immune modulation of T cells and natural killer …

Y Peng, M Zhan, A Karpus, Y Zou, S Mignani… - ACS …, 2024 - ACS Publications
Fully mobilizing the activities of multiple immune cells is crucial to achieve the desired tumor
immunotherapeutic efficacy yet still remains challenging. Herein, we report a nanomedicine …