Placental Exosomes as Biomarkers for Maternal Diseases: Current Advances in Isolation, Characterization, and Detection

CM Nguyen, M Sallam, MS Islam, K Clack, N Soda… - ACS …, 2023 - ACS Publications
Serving as the interface between fetal and maternal circulation, the placenta plays a critical
role in fetal growth and development. Placental exosomes are small membrane-bound …

Inflammation and oxidative stress induced by obesity, gestational diabetes, and preeclampsia in pregnancy: role of high-density lipoproteins as vectors for bioactive …

AS Jiménez-Osorio, E Carreón-Torres, E Correa-Solís… - Antioxidants, 2023 - mdpi.com
Inflammation and oxidative stress are essential components in a myriad of pathogenic
entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different …

The pathophysiological, genetic, and hormonal changes in preeclampsia: A systematic review of the molecular mechanisms

YT Chiang, KM Seow, KH Chen - International Journal of Molecular …, 2024 - mdpi.com
Preeclampsia, a serious complication of pregnancy, involves intricate molecular and cellular
mechanisms. Fetal microchimerism, where fetal cells persist within maternal tissues and in …

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia

Q Zhang, CL Lee, T Yang, J Li, Q Zeng, X Liu, Z Liu… - Science …, 2023 - science.org
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with
defective trophoblast differentiation and functions at implantation, but manifestation of its …

Circulating extracellular vesicular microRNA signatures in early gestation show an association with subsequent clinical features of pre-eclampsia

S Ghosh, S Thamotharan, J Fong, MYY Lei… - Scientific Reports, 2024 - nature.com
In a prospective cohort of subjects who subsequently developed preeclampsia (PE, n= 14)
versus remaining healthy (NORM, n= 12), early gestation circulating extracellular vesicles …

Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant

LA Bartho, E Keenan, SP Walker, TM MacDonald… - …, 2023 - thelancet.com
Background Lipids serve as multifunctional metabolites that have important implications for
the pregnant mother and developing fetus. Abnormalities in lipids have emerged as …

Quantitative point of care tests for timely diagnosis of early‐onset preeclampsia with high sensitivity and specificity

S Masoumeh Ghorbanpour, S Wen… - Angewandte …, 2023 - Wiley Online Library
Preeclampsia is a heterogeneous and multiorgan cardiovascular disorder of pregnancy.
Here, we report the development of a novel strip‐based lateral flow assay (LFA) using …

Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis

M Danielli, RC Thomas, CL Gillies, J Hu, K Khunti… - Heliyon, 2022 - cell.com
Pre-eclampsia is one of the most common pregnancy complications, and a major cause of
fetal and maternal morbidity and mortality globally. Diagnosis currently takes place in the …

Protein biomarker signatures of preeclampsia-a longitudinal 5000-multiplex proteomics study

MHL Degnes, AC Westerberg, IJ Andresen… - Scientific Reports, 2024 - nature.com
We aimed to explore novel biomarker candidates and biomarker signatures of late-onset
preeclampsia (LOPE) by profiling samples collected in a longitudinal discovery cohort with a …

[HTML][HTML] Prediction of pre-eclampsia with machine learning approaches: Leveraging important information from routinely collected data

SA Tiruneh, DL Rolnik, HJ Teede, J Enticott - International Journal of …, 2024 - Elsevier
Background Globally, pre-eclampsia (PE) is a leading cause of maternal and perinatal
morbidity and mortality. PE prediction using routinely collected data has the advantage of …