General anesthesia is one of the most common clinical anesthesia methods. Many studies
have suggested that 5-HT plays an important role in the mechanism of general anesthesia …

Neuropathic pain is a refractory pain state, and its mechanism is still not clear. Previous
studies have shown that the purine receptor P2X4R expressed on hyperactive microglia in …

A unique nucleus, the cerebrospinal fluid (CSF)-contacting nucleus, has recently been
recognized in the brain parenchyma. The outstanding feature of this nucleus is that the …

To establish an entirely cerebrospinal fluid (CSF)-contacting nucleus-deficient model
animal, we used cholera toxin B subunit (CB)-saporin (SAP), which is an analog of CB-HRP …

The cerebrospinal fluid-contacting nucleus (CSF-CN) has been demonstrated to be involved
in neuropathic pain, but the underlying molecular mechanisms remain unclear. Previous …

The cerebrospinal fluid (CSF)-contacting nucleus is implicated in the descending inhibitory
pathway in pain processing, whereas the cellular and molecular mechanisms underpinning …

The brainstem plays an important role in controlling sodium and water homeostasis. It is a
major regulatory site for autonomic and motor functions. Moreover, it integrates …

Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting
nucleus) is correlated with the development and recurrence of pain. A recent research …

The contribution of the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) and
adrenomedullin (ADM) to the developmental modulation of stressful events remains …

Increasing evidence suggests that the cerebrospinal fluid-contacting nucleus (CSF-
contacting nucleus) mediates the transduction and regulation of pain signals. However, the …