Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …

G4 DNA is a non-canonical DNA structure consisting of a stacked array of Gquartets held
together by base pairing between guanine bases. The formation of G4 DNA requires a …

G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

For over two decades, the prime objective of the chemical biology community studying G-
quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to …

Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA)
structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we …

Sequences capable of forming quadruplex or G4 DNA are prevalent in the promoter regions.
The transformation from canonical to non-canonical secondary structure apparently …

Aging is a prominent risk factor for many neurodegenerative disorders, such as Alzheimer's
disease (AD). Alzheimer's disease is characterized by progressive cognitive decline …

Noncanonical base pairing between four guanines (G) within single-stranded G-rich
sequences leads to formation of а G-quartet. Self-stacking of G-quartets results in a …

The importance of local DNA structures in the regulation of basic cellular processes is an
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes are …

DNA has the ability to form polymorphic structures like canonical duplex DNA and non-
canonical triplex DNA, Cruciform, Z-DNA, G-quadruplex (G4), i-motifs, and hairpin structures …