Modulation and function of Pumilio proteins in cancer

ILZ Silva, AA Kohata, P Shigunov - Seminars in cancer biology, 2022 - Elsevier
Post-transcriptional regulation is involved in tumorigenesis, and in this control, RNA-binding
proteins are the main protagonists. Pumilio proteins are highly conserved RNA-binding …

MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors

L Urbanski, M Brugiolo, SH Park, BL Angarola… - Cell reports, 2022 - cell.com
MYC is dysregulated in> 50% of cancers, but direct targeting of MYC has been clinically
unsuccessful. Targeting downstream MYC effector pathways represents an attractive …

Circular RNA RBM33 contributes to cervical cancer progression via modulation of the miR-758-3p/PUM2 axis

Y Ding, X Yuan, W Gu - Journal of Molecular Histology, 2021 - Springer
Cervical cancer (CC) is a gynecological malignant tumor. Circular RNA
(hsa_circ_0001772)(circRBM33) is implicated in the tumorigenesis of cancers …

Comprehensive analysis of differentially expressed profiles of mRNA N6-methyladenosine in colorectal cancer

N Li, Q Guo, Q Zhang, BJ Chen, XA Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Aim: To comprehensively profile the landscape of the mRNA N6-methyladenosine (m6A)
modification in human colorectal cancer (CRC). Methods: Methylated RNA …

LncRNA TTN‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p

L Shen, Y Wu, A Li, L Li, L Shen… - Oncology …, 2020 - spandidos-publications.com
Increasing research has demonstrated that lncRNAs participate in the development of
multiple cancer types. However, the role of TTN‑AS1 in endometrial cancer (EC) remains …

Pumilio2 promotes growth of mature neurons

R Schieweck, EC Schöneweiss, M Harner… - International Journal of …, 2021 - mdpi.com
RNA-binding proteins (RBPs) are essential regulators controlling both the cellular
transcriptome and translatome. These processes enable cellular plasticity, an important …

BTG1 inhibits malignancy as a novel prognosis signature in endometrial carcinoma

Y Li, J Huo, J He, Y Zhang, X Ma - Cancer Cell International, 2020 - Springer
Background Endometrial carcinoma (EC) is one of the three major malignant tumors of the
female reproductive system. In recent years, the incidence and mortality rate of EC have …

Genomic and epigenomic profile of uterine smooth muscle tumors of uncertain malignant potential (STUMPs) revealed similarities and differences with leiomyomas …

D Conconi, S Redaelli, AA Lissoni, C Cilibrasi… - International Journal of …, 2021 - mdpi.com
Uterine smooth muscle tumors of uncertain malignant potential (STUMPs) represent a
heterogeneous group of tumors that cannot be histologically diagnosed as unequivocally …

[HTML][HTML] Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2

L Xu, B Zhang, W Li - Molecular Medicine Reports, 2021 - spandidos-publications.com
Ovarian cancer (OC) is a major contributor to cancer‑related mortality in women. Despite
numerous drugs being available for the treatment and improving the prognosis of OC …

Norad Competently Binds with Pum2 to Regulate Neuronal Apoptosis and Play a Neuroprotective Role After SAH in Mice

J Gu, J Lu, J Yang, Y Liu, X Zhu, J Zhang, H Shen, X Li… - Neuroscience, 2023 - Elsevier
Subarachnoid Hemorrhage (SAH) is a cerebrovascular disorder that has been found to have
severe consequences, including a high mortality and disability rate. Research has indicated …