Loss of muscle proteins is a deleterious consequence of chronic kidney disease (CKD) that
causes a decrease in muscle strength and function, and can lead to a reduction in quality of …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle
growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite …

Muscle performance is influenced by turnover of contractile proteins. Production of new
myofibrils and degradation of existing proteins is a delicate balance, which, depending on …

Sarcopenic obesity is becoming a global health concern, owing to the rising older
population, causing cardiometabolic morbidity and mortality. Loss of muscle exceeding …

In 1961, the satellite cell was first identified when electron microscopic examination of
skeletal muscle demonstrated a cell wedged between the plasma membrane of the muscle …

Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

The Pax7 transcription factor is required for muscle satellite cell biogenesis and specification
of the myogenic precursor lineage. Pax7 is expressed in proliferating myoblasts but is …

How regeneration cues are converted into the epigenetic information that controls gene
expression in adult stem cells is currently unknown. We identified an inflammation-activated …

Abstract Objective The Vitamin D receptor (VDR) has been positively associated with
skeletal muscle mass, function and regeneration. Mechanistic studies have focused on the …