Antimicrobial peptides–Advances in development of therapeutic applications

HX Luong, TT Thanh, TH Tran - Life sciences, 2020 - Elsevier
The severe infection is becoming a significant health problem which threaten the lives of
patients and the safety and economy of society. In the way of finding new strategy …

Biotechnological advances in Bacillus thuringiensis and its toxins: Recent updates

U Azizoglu, G Salehi Jouzani, E Sansinenea… - … Science and Bio …, 2023 - Springer
Bacillus thuringiensis (Bt) and its products are commonly used to control insect pests. The
main issue with these bacteria is their limited field stability. These constraints fueled interest …

The Cytocidal Spectrum of Bacillus thuringiensis Toxins: From Insects to Human Cancer Cells

G Mendoza-Almanza, EL Esparza-Ibarra… - Toxins, 2020 - mdpi.com
Bacillus thuringiensis (Bt) is a ubiquitous bacterium in soils, insect cadavers, phylloplane,
water, and stored grain, that produces several proteins, each one toxic to different biological …

[HTML][HTML] Bacillus thuringiensis: From biopesticides to anticancer agents

EN Santos, LP Menezes, SS Dolabella, A Santini… - Biochimie, 2022 - Elsevier
Bacillus thuringiensis (Bt) is a ubiquitous bacterium that produces several proteins that are
toxic to different invertebrates such as insects, nematodes, mites, and also some protozoans …

Specific Cytotoxic Effects of Parasporal Crystal Proteins Isolated from Native Saudi Arabian Bacillus thuringiensis Strains against Cervical Cancer Cells

MAM Aboul-Soud, MZ Al-Amri, A Kumar, YA Al-Sheikh… - Molecules, 2019 - mdpi.com
Currently, global efforts are being intensified towards the discovery of local Bacillus
thuringiensis (Bt) isolates with unique anticancer properties. Parasporins (PS) are a group of …

Structural and functional validation of a cloned parasporin from Bacillus thuringiensis isolate KAU 41 native to Western Ghats of India

D Girija, K Deepa, T Chubicka… - Proteins: Structure …, 2023 - Wiley Online Library
Abstract Parasporins of Bacillus thuringiensis (Bt) exhibit specific toxicity to cancer cells.
PCR based mining has identified apoptosis inducing parasporin in KAU41 Bt isolate from …

Glabralysins, Potential New β-Pore-Forming Toxin Family Members from the Schistosomiasis Vector Snail Biomphalaria glabrata

D Lassalle, G Tetreau, S Pinaud, R Galinier… - Genes, 2020 - mdpi.com
Biomphalaria glabrata is a freshwater Planorbidae snail. In its environment, this mollusk
faces numerous microorganisms or pathogens, and has developed sophisticated innate …

Parasporin A13-2 of Bacillus thuringiensis Isolates from the Papaloapan Region (Mexico) Induce a Cytotoxic Effect by Late Apoptosis against Breast Cancer Cells

DB Borin, K Castrejón-Arroyo, A Cruz-Nolasco… - Toxins, 2021 - mdpi.com
The protein A13-2 was obtained from Bacillus thuringiensis strains isolated from the
Papaloapan watershed region (Oaxaca, Mexico). The cytotoxic activity of parasporal …

[HTML][HTML] Enhancing the Cytotoxicity and Apoptotic Efficacy of Parasporin-2-Derived Variants (Mpp46Aa1) on Cancer Cell Lines

JS Alarcón-Aldana, L Visser, NJ Rueda-Forero… - Toxins, 2024 - mdpi.com
Parasporin PS2Aa1, recently renamed Mpp46Aa1, is an anti-cancer protein known for its
selectivity against various human cancer cell lines. We genetically modified native PS2Aa1 …

In Vitro Cytotoxicity of Parasporins from Native Algerian Bacillus thuringiensis Strains Against Laryngeal and Alveolar Cancers

L Aberkane, A Nacer-Khodja, Z Djenane… - Current …, 2020 - Springer
Parasporins (PS), a class of non-insecticidal and non-hemolytic crystal proteins of Bacillus
thuringiensis (Bt), are being explored as promising anti-cancer agents due to their specific …