In addition to involvement in vascular endothelium-smooth muscle communication, the
secretion of and receptors for, endothelins are widely distibuted. Two cloned receptor …

The methodology of regioselective cysteine pairings in synthetic multiple‐cystine peptides
has progressed in the past years to an efficiency that allows for at least three specific inter …

Air re-oxidation of fully reduced human endothelin-1 under optimized conditions yields the
natural isomer with parallel disulfide bridges and the non-natural isomer with crossed …

The three–dimensional structure of the vasoactive polypeptide endothelin, the most potent
vasocontrictor yet identified, has been determined by X–ray crystallography to 2.18 Å …

In this study we have investigated the determination of proper time step in molecular
dynamics simulation. Since the molecular dynamics is mathematically related to nonlinear …

The large abundance of bioactive single‐and multiple‐stranded cystine‐rich peptides in
nature has fostered the development of orthogonal thiol‐protection schemes and of efficient …

With the advent of the first generation of both selective and nonselective endothelin
antagonists being a relatively recent event, the manifold therapeutic potentials of these …

Bioactive peptides of different sources and biological functionalities, like endothelins,
sarafotoxins, bee and scorpion venom toxins, contain a consensus cystine framework, Cys …

In recent years, NMR studies of peptides have been overshadowed by the rapid progress of
NMR studies of proteins. The techniques developed for proteins, both those used for …

The endothelins and sarafotoxins are two structurally related families of potent vasoactive
peptides. Although the physiological functions of these peptides are not entirely clear, the …