Review of the endocannabinoid system

HC Lu, K Mackie - Biological Psychiatry: Cognitive Neuroscience and …, 2021 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …

Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021 - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials

JS Aday, BD Heifets, SD Pratscher, E Bradley… - …, 2022 - Springer
Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …

Changes in delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) concentrations in cannabis over time: systematic review and meta‐analysis

TP Freeman, S Craft, J Wilson, S Stylianou… - …, 2021 - Wiley Online Library
Background and aims Cannabis products with high delta‐9‐tetrahydrocannabinol (THC)
concentrations carry an increased risk of addiction and mental health disorders, while it has …

[HTML][HTML] Lower-Risk Cannabis Use Guidelines (LRCUG) for reducing health harms from non-medical cannabis use: A comprehensive evidence and recommendations …

B Fischer, T Robinson, C Bullen, V Curran… - International Journal of …, 2022 - Elsevier
Background Cannabis use is common, especially among young people, and is associated
with risks for various health harms. Some jurisdictions have recently moved to …

Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD: THC ratios

A Englund, D Oliver, E Chesney, L Chester… - …, 2023 - nature.com
As countries adopt more permissive cannabis policies, it is increasingly important to identify
strategies that can reduce the harmful effects of cannabis use. This study aimed to determine …

Assessment of orally administered Δ9-tetrahydrocannabinol when coadministered with cannabidiol on Δ9-tetrahydrocannabinol pharmacokinetics and …

CA Zamarripa, TR Spindle, R Surujunarain… - JAMA Network …, 2023 - jamanetwork.com
Importance Controlled clinical laboratory studies have shown that cannabidiol (CBD) can
sometimes attenuate or exacerbate the effects ofΔ9-tetrahydrocannabinol (Δ9-THC). No …

Cannabidiol (CBD) use in psychiatric disorders: A systematic review

S Bonaccorso, A Ricciardi, C Zangani, S Chiappini… - Neurotoxicology, 2019 - Elsevier
Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the most represented
phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different …

How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

AM Freeman, K Petrilli, R Lees, C Hindocha… - Neuroscience & …, 2019 - Elsevier
The recent liberalisation of cannabis regulation has increased public and scientific debate
about its potential benefits and risks. A key focus has been the extent to which cannabidiol …

'Standard THC units': a proposal to standardize dose across all cannabis products and methods of administration

TP Freeman, V Lorenzetti - Addiction, 2020 - Wiley Online Library
Abstract Background and Aims Cannabis products are becoming increasingly diverse, and
vary considerably in concentrations of∆ 9‐tetrahydrocannabinol (THC) and cannabidiol …