The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …

With the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells …

Shortly after the discovery of interleukin 17 (IL-17)-producing CD4+ helper T cells (TH17
cells), it was found that γδ T cells can also secrete large amounts of this pro-inflammatory …

As interest in γδ T cells grows rapidly, what key points are emerging, and where is caution
warranted? γδ T cells fulfill critical functions, as reflected in associations with vaccine …

The role of IL-17 in cancer remains controversial. Emerging evidence suggests that during
early oncogenesis IL-17 supports tumor growth, whereas in established tumors IL-17 …

Epithelial and mucosal barriers are critical interfaces physically separating the body from the
outside environment and are the tissues most exposed to microorganisms and potential …

Cancer-associated inflammation mobilizes a variety of leukocyte populations that can inhibit
or enhance tumor cell growth in situ. These subsets include γδ T cells, which can infiltrate …

The thymus generates T cells that are generally functionally immature and thus require
peripheral activation for differentiation into effector lymphocytes. Notable exceptions to this …