Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …

The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …

Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …

OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …

Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …

Objective To investigate the underlying mechanisms behind changes in glucose
homeostasis with delivery of propionate to the human colon by comprehensive and …

Branched-chain amino acids (BCAAs) are important nutrient signals that have direct and
indirect effects. Frequently, BCAAs have been reported to mediate antiobesity effects …

Type 1 and type 2 diabetes mellitus (DM) are chronic diseases that affect nearly 425 million
people worldwide, leading to poor health outcomes and high health care costs. High …

Predicting longer-term mortality risk requires collection of clinical data, which is often
cumbersome. Therefore, we use a well-standardized metabolomics platform to identify …