Emerging antifungal targets and strategies

M Ivanov, A Ćirić, D Stojković - International Journal of Molecular …, 2022 - mdpi.com
Despite abundant research in the field of antifungal drug discovery, fungal infections remain
a significant healthcare burden. There is an emerging need for the development of novel …

[HTML][HTML] Drug resistance and novel therapeutic approaches in invasive candidiasis

SE Murphy, T Bicanic - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Candida species are the leading cause of invasive fungal infections worldwide and are
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …

Selective metal chelation by a thiosemicarbazone derivative interferes with mitochondrial respiration and ribosome biogenesis in Candida albicans

X Duan, Z Xie, L Ma, X Jin, M Zhang, Y Xu… - Microbiology …, 2022 - Am Soc Microbiol
Metal chelation is generally considered as a promising antifungal approach but its specific
mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert …

Cinnamon essential oil induced microbial stress metabolome indicates its active food packaging efficiency when incorporated into poly vinyl alcohol, engineered with …

A Jose, M Mathew, AS Mathew, R Aswani… - International Journal of …, 2024 - Elsevier
Abstract In the study, Poly Vinyl Alcohol (PVA) films engineered with the nanoparticles and
essential oils have been developed as efficient alternative to the currently used food …

[HTML][HTML] Prospects for anti-Candida therapy through targeting the cell wall: A mini-review

S Ahmadipour, RA Field, GJ Miller - The Cell Surface, 2021 - Elsevier
The impact of fungal infections on humans is a serious public health issue that has received
much less attention than bacterial infection and treatment, despite ever-increasing incidence …

Antimicrobial Activities of Stigmasterol from Piper crocatum In Vitro and In Silico

S Lestari, D Kurnia, T Mayanti… - Journal of …, 2024 - Wiley Online Library
The high incidence of oral health issues and antibiotic resistance has stimulated research
into discovering novel antimicrobial drugs. Prior evidence suggests that red betel leaves …

Activity of poly (methacrylic acid)‐silver nanoparticles on fluconazole‐resistant Candida albicans strains: Synergistic and cytotoxic effects

CMC Falcão, A Andrade, VN Holanda… - Journal of Applied …, 2022 - academic.oup.com
Aims To synthesize and evaluate the antifungal activity of poly (methacrylic acid)‐silver
nanoparticles (PMAA‐AgNPs) against nine Candida albicans isolated from clinical …

Enolase in Meyerozyma guilliermondii strain SO: Sequential and structural insights of MgEno4581 as a putative virulence factor and host-fungal interactions through …

AI Amran, SJ Lim, NDM Noor, AB Salleh… - Microbial Pathogenesis, 2023 - Elsevier
Meyerozyma guilliermondii is a rare opportunistic fungal pathogen that causes deadly
invasive candidiasis in human. M. guilliermondii strain SO is a local yeast isolate that …

Pseudocercospora fijiensis Conidial Germination Is Dominated by Pathogenicity Factors and Effectors

KG Carreón-Anguiano, R Gómez-Tah, E Pech-Balan… - Journal of Fungi, 2023 - mdpi.com
Conidia play a vital role in the survival and rapid spread of fungi. Many biological processes
of conidia, such as adhesion, signal transduction, the regulation of oxidative stress, and …

Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus

S Nguyen, B Jovcevski, TL Pukala… - … Section D: Structural …, 2022 - journals.iucr.org
Purine biosynthesis is a fundamental cellular process that sustains life by maintaining the
intracellular pool of purines for DNA/RNA synthesis and signal transduction. As an integral …