ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …

The zinc finger antiviral protein (ZAP) restricts the replication of a broad range of RNA and
DNA viruses. ZAP directly binds viral RNA, targeting it for degradation and inhibiting its …

Detecting viral infection is a key role of the innate immune system. The genomes of some
RNA viruses have a high CpG dinucleotide content relative to most vertebrate cell RNAs …

ZAP is an antiviral protein that binds to and depletes viral RNA, which is often distinguished
from vertebrate host RNA by its elevated CpG content. Two ZAP cofactors, TRIM25 and …

The host interferon pathway upregulates intrinsic restriction factors in response to viral
infection. Many of them block a diverse range of viruses, suggesting that their antiviral …

Summary PARP13/ZAP (zinc-finger antiviral protein) acts against multiple viruses by
promoting degradation of viral mRNA. PARP13 has four N-terminal zinc (Zn) fingers that …

Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is
associated with multiple disease processes such as infections and chronic inflammatory …

Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …