Vascular endothelial cells are ordinarily quiescent in adult humans and divide less than
once per decade. When tumors reach a size of about 0.2–2.0 mm in diameter, they become …

Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …

Although blocking the binding of vascular endothelial growth factor (VEGF) to neuropilin-2
(NRP2) on tumor cells is a potential strategy to treat aggressive carcinomas, a lack of …

The semaphorins and their receptors, the neuropilins and the plexins, were originally
characterized as constituents of the complex regulatory system responsible for the guidance …

Background: Although cigarette smoking is the major risk factor for lung cancer, only 7% of
female lung cancer patients in Taiwan have a history of smoking. The genetic mechanisms …

Neuropilins are multifunctional non–tyrosine kinase receptors that bind to class 3
semaphorins and vascular endothelial growth factor. NRP-1 and NRP-2 were first identified …

Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …

Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system
development by regulating angiogenesis and axon guidance cues. Several published …

Initially found expressed in neuronal and then later in endothelial cells, it is well established
that the transmembrane glycoproteins neuropilin‐1 (NRP1) and neuropilin‐2 (NRP2) play …

Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential
for many physiological processes, and aberrant angiogenesis contributes to some of the …