The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Mammalian embryonic development is a tightly regulated process that, from a single zygote,
produces a large number of cell types with hugely divergent functions. Distinct cellular …

Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene
repression. Organized within multiprotein complexes, they regulate developmental genes in …

Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of
chromatin domains repressive to transcription through catalysis of methylation of histone H3 …

Keratinocyte differentiation is an essential process for epidermal stratification and stratum
corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start …

Epithelia cover the surfaces and line the cavities of the body. Recent studies have
highlighted the existence of multiple stem cell compartments within individual epithelia that …

The first genes composing the Polycomb group (PcG) were identified 50 years ago in
Drosophila melanogaster as essential developmental functions that regulate the correct …

It is becoming clear that interconnected functional gene networks, rather than individual
genes, govern stem cell self-renewal and differentiation. To identify epigenetic factors that …

The nucleus is a complex and highly compartmentalized organelle, which undergoes major
organization changes during cell differentiation, allowing cells to become specialized and …

Somatic progenitors suppress differentiation to maintain tissue self-renewal. The
mammalian SWI/SNF chromatin-remodeling complex regulates nucleosome packaging to …