Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

The core of the neurotransmitter release machinery is formed by SNARE complexes, which
bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1 …

▪ Abstract The SNARE superfamily has become, since its discovery approximately a decade
ago, the most intensively studied element of the protein machinery involved in intracellular …

This review focuses on the so-called SNARE (soluble N-ethyl maleimide sensitive factor
attachment protein receptor) proteins that are involved in exocytosis at the pre-synpatic …

During exocytosis a four‐helical coiled coil is formed between the three SNARE proteins
syntaxin, synaptobrevin and SNAP‐25, bridging vesicle and plasma membrane. We have …

Synaptotagmin acts as a Ca2+ sensor in neurotransmitter release through its two C2
domains. Ca2+-dependent phospholipid binding is key for synaptotagmin function, but it is …

SNAREs are essential for intracellular membrane fusion. Using EPR, we determined the
structure of the transmembrane domain (TMD) of the vesicle (v)-SNARE Snc2p involved in …

SNARE proteins and synaptotagmin are key components of the complex machinery that
controls Ca 2+-triggered neurotransmitter release but their mechanisms of action are under …

Neuronal communication depends on exquisitely regulated membrane fusion between
synaptic vesicles and presynaptic neurons, which results in neurotransmitter release in …