Major depressive disorder (MDD) is a common psychiatric disorder effecting approximately
121 million people worldwide and recent reports from the World Health Organization (WHO) …

Multiple biological processes throughout development require intracellular vesicular
trafficking, where the SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment …

Chronic stress is known to perturb serotonergic regulation in the brain, leading to mood,
learning and memory impairments and increasing the risk of developing mood disorders …

The communication between neurons constitutes the basis of all neural activities, and
synaptic vesicle exocytosis is the fundamental biological event that mediates most …

Symptoms of depressive disorders such as anhedonia and despair can be a product of an
aberrant adaptation to stress conditions. Chronic unpredictable stress model (CUS) can …

Agmatine is an endogenous neuromodulator that has been shown to have beneficial effects
in the central nervous system, including antidepressant-like effects in animals. In this study …

The hippocampus is sensitive to stress which activates norepinephrine terminals deriving
from the locus coeruleus. Melatonin exerts positive effects on the hippocampal neurogenic …

Abstract Synaptosomal Associated Protein-25 kilodaltons (SNAP-25) is an integral member
of the SNARE complex. This complex is essential for calcium-triggered synaptic vesicular …

This study investigated the effects of melatonin treatment on adrenal catecholamine content,
synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress …

Depressive pseudodementia (DPD) is a debilitating cognitive dysfunction that accompanies
major and/or frequent depressive attacks. DPD has gained significant research attention …